After the beloved TV host of the popular wildlife show "Strange Wilderness" passes on to the great nature special in the sky, his son Peter Gaulke (Steve Zahn) takes over the series--and things are never the same. When the ratings sink to an all-time low and the show is about to be cancelled, Pete and his filmmaking partner Fred Wolf (Allen Covert) realize they have to come up with "something big" to save the series.
Pete gets a visit from his father's backwoods survivalist friend Bill Calhoun, who offers to sell him a map to Bigfoot's jungle hideout. Pete and Fred hire two new crew members, Bill Whitaker (Kevin Heffernan) and Cheryl (Ashley Scott), and set off for Ecuador in their dilapidated RV. From the start, however, the ambitious expedition is beset with disasters.